Figure 6.
Tumor cells decrease in SCH66336-treated mice. Splenocytes were isolated and stained with antibodies to IgMa and B220 to detect the transgenic lymphoma cells. The percent of viable splenocytes positive for both markers is shown for unmanipulated C57BL/6 mice (Wild-type) or mice transplanted with 106 tumor cells 18 days earlier (Transplant recipient). Results from untreated mice are shown with black bars and from transplant-recipient mice treated with 1.56 mg SCH66336 by oral gavage twice daily for 3 days with shaded bars. The average and standard deviation for 4 mice in each group is shown.