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. 2008 May 28;105(22):7797–7802. doi: 10.1073/pnas.0800928105

Fig. 3.

Fig. 3.

PI3K/mTOR inhibition initiates a Treg-like transcriptional program in newly activated T cells. (a) Gene expression differences between Treg cells versus naive CD4 T cells and in 24 h PI3K/mTOR inhibitor-treated cells versus naive CD4 T cells. Shown are the numbers of up- and down-regulated transcripts and the intersection of expression differences between Treg and Foxp3 induced cells. (b) Functional annotation of coregulated transcripts in Treg cells and Foxp3 induced cells relative to naive CD4 T cells, using DAVID. (c) microRNA expression by Treg cells and Foxp3 induced cells compared by qPCR. miR-142-3p and miR-21 are shown as examples for Treg-like and non-Treg-like microRNA expression by Foxp3 induced cells. The expression profiles of eight other microRNAs are listed.