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. 2008 May 28;105(22):7833–7838. doi: 10.1073/pnas.0802063105

Fig. 1.

Fig. 1.

Predicted structural motifs of mouse Cidea and FSP27 based on sequence homology with mouse perilipin. FSP27 (amino acids 2–29) and Cidea (amino acids 2–28) show sequence similarity of 32% and 22%, respectively, with a portion of the adipophilin-like sequence of perilipin (amino acids 11–38, I). In perilipin, amino acids 120–152 (II) represents a section of the triacyglycerol shielding region that plays a role in shielding stored triacylglycerol from cytosolic lipases. It has a sequence similarity of 40% with FSP27 (amino acids 46–77) and 51% with Cidea (amino acids 38–69). Similarly, lipid droplet targeting and anchoring regions of perilipin (amino acids 313–352, III; and amino acids 365–391, IV) have sequence similarities of 40% and 30% with respective sequences of FSP27 (amino acids 137–173 and 174–200) and 38% and 48% similarities with Cidea (amino acids 122–158 and 159–185).