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. 2008 May 28;105(22):7833–7838. doi: 10.1073/pnas.0802063105

Fig. 6.

Fig. 6.

Cidea mRNA levels are higher in WAT of obese, insulin-sensitive subjects as compared with obese, insulin-resistant subjects matched for BMI. (a) BMI and HOMA-IR comparisons of insulin-sensitive (n = 13) and insulin-resistant (n = 7) obese human subjects. Please note that BMI does not predict the degree of insulin resistance in this cohort of obese patients. HOMA-IR of 2.3 was used as a cut point to categorize the obese patients as insulin-sensitive (HOMA-IR ≤ 2.3) or insulin-resistant. (b) Real-time PCR analysis depicting a fold change in mRNA levels of various genes in omental adipose tissue of obese, insulin-sensitive individuals as compared with obese, insulin-resistant subjects. *, P < 0.0001; **, P < 0.001; ***, P < 0.05. (c) Real-time PCR analysis depicting a fold change in mRNA levels of various genes in s.c. adipose tissue of obese, insulin-sensitive individuals as compared with obese, insulin-resistant subjects. *, P < 0.0001; ***, P < 0.05. Fresh human omental and s.c. tissues were obtained under informed consent from patients undergoing gastric bypass surgery (University of Massachusetts Medical School Institution Review Boards docket number H-11033). Tissues were frozen after procurement and stored at −80°C for subsequent RNA and protein extractions.