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Further study of the dimer interface. (a) Distinguishing intradimer from interdimer cross-linking. The numbers at the bottom of each gel indicate the cysteine position. (b and c) Specificity of cross-linking in the S1–S1 dimer interface. Amino acids are shown in single-letter code. Transmembrane region of S1 and the adjacent loop (117 to 128) were subjected to air oxidation (b) and CuP-mediated oxidation (c).
