Table 4. Distribution of prostate cancer cases and controls, OR and corresponding 95% CI according to stage, grade, and BMI (kg m−2) at diagnosis/interview and at age 30. Italy, 1991–2002.
|
Stage (TNM) |
Grade (Gleason score) |
||||||||
|---|---|---|---|---|---|---|---|---|---|
|
I–II |
III–IV |
2–6 |
7–10 |
||||||
| Controls | Cases | OR (95% CI) | Cases | OR (95% CI) | Cases | OR (95% CI) | Cases | OR (95% CI) | |
| BMI at diagnosis/interview | |||||||||
| <24.22 | 368 | 79 | 1 | 45 | 1 | 126 | 1 | 69 | 1 |
| 24.22 to <26.18 | 356 | 88 | 1.12 (0.78–1.60) | 67 | 1.47 (0.96–2.25) | 153 | 1.27 (0.95–1.69) | 102 | 1.49 (1.05–2.12) |
| 26.18 to <28.41 | 365 | 77 | 0.91 (0.63–1.32) | 59 | 1.27 (0.83–1.96) | 125 | 0.98 (0.72–1.32) | 111 | 1.57 (1.11–2.22) |
| ⩾28.41 | 358 | 76 | 1.02 (0.70–1.47) | 60 | 1.40 (0.91–2.16) | 134 | 1.14 (0.85–1.53) | 102 | 1.61 (1.13–2.28) |
| χ2 trend | 0.07 | P=0.79 | 1.38 | P=0.24 | 0.06 | P=0.81 | 6.38 | P=0.01 | |
| BMI at age 30 | |||||||||
| <22.65 | 492 | 102 | 1 | 59 | 1 | 157 | 1 | 112 | 1 |
| 22.65 to <24.69 | 430 | 109 | 1.21 (0.87–1.67) | 88 | 1.87 (1.29–2.72) | 190 | 1.50 (1.16–1.95) | 139 | 1.60 (1.19–2.15) |
| ⩾24.69 | 459 | 107 | 1.20 (0.87–1.65) | 84 | 1.62 (1.11–2.35) | 180 | 1.36 (1.04–1.76) | 129 | 1.39 (1.03–1.87) |
| χ2 trend | 1.25 | P=0.26 | 5.79 | P=0.02 | 5.12 | P=0.02 | 4.64 | P=0.03 | |
a
Estimates from multiple logistic regression equations, including terms for age (quinquennia), study centre, education, physical activity, and family history of prostate cancer.