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. 2004 May 25;90(12):2402–2410. doi: 10.1038/sj.bjc.6601888

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Copyright © 2004 Cancer Research UK

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In the first stage of ADEPT, the intravenously administered antibody–enzyme fusion protein MFECPHis is allowed to localise in the tumour. In the second stage, prodrug ZD2767P, based on a bis-iodo-phenol mustard is given after clearance of enzyme from the circulation. CP cleaves the glutamate moiety to generate the active drug ZD2767D.