Table 3. Tumour TP changes by each regimen.
| Regimen | n | Gain in TP score (mean) | Up (%) | NC (%) | Down (%) |
|---|---|---|---|---|---|
| AC/EC | |||||
| Tumour | 14 | 4.3 | 13 (92.9) | 1 (7.1) | 0 (0.0) |
| Stroma | 14 | 3.6 | 12 (85.7) | 2 (14.3) | 0 (0.0) |
| FAC/FEC | |||||
| Tumour | 58 | 0.7 | 24 (41.4) | 22 (37.9) | 12 (20.7) |
| Stroma | 58 | −0.9 | 10 (17.2) | 25 (43.1) | 23 (39.7) |
| TXT-containing regimen | |||||
| Tumour | 20 | 1.8 | 13 (65.0) | 4 (20.0) | 3 (15.0) |
| Stroma | 20 | 0.0 | 8 (40.0) | 6 (30.0) | 6 (30.0) |
| Total | |||||
| Tumour | 92 | — | 50 (54.4) | 27 (29.3) | 15 (16.3) |
| Stroma | 92 | — | 30 (32.6) | 33 (35.9) | 29 (31.5) |
|
Tumour |
Stroma |
||||
| Regimen compared | t-test | M–H | t-test | M–H | |
| AC/EC vs FAC/FEC | <0.0001 | 0.0114 | <0.0001 | <0.0001 | |
| FAC/FEC vs TXT | 0.2287 | 0.5700 | 0.0580 | 0.0021 | |
| AC/EC vs TXT | 0.1527 | 0.5616 | 0.0339 | 0.7773 | |
Up=upregulated; NC=no change; Down=downregulated; AC=adriamycin (ADR) and cyclophosphamide (CPA); EC=epirubicin (EPI) and CPA; FAC=5-fluorouracil (5-FU), ADR, and CPA; FEC=5-FU, EPI, and CPA; P-values with Bonferroni's correction, adjusted by tumour size; M–H=Mantel–Haenszel test.