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. 2004 Jun 1;90(12):2418–2424. doi: 10.1038/sj.bjc.6601864

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Copyright © 2004 Cancer Research UK

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Effect of aplidine on angiogenesis in the CAM. Sponges loaded with PBS (spontaneous, basal angiogenesis), VEGF or FGF-2 and aplidine at the indicated concentration were implanted on CAMs on day 8 of incubation. On day 12, blood vessels entering the sponges or the implants within the focal plane of the CAM were counted by two observers in a double-blind manner at × 50 magnification. Results are expressed as the percentage of control response (mean and s.d., n=10). Vascular endothelial growth factor and FGF-2 induced a 4.7- and 4.2-fold increase in angiogenic response (38±7 and 34±4 vessels, respectively) compared to control (8±2 vessels).