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. 2004 Jan 20;90(2):542–548. doi: 10.1038/sj.bjc.6601538

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Copyright © 2004 Cancer Research UK

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(A–D) Clonogenic survival curves for cells given irradiation alone (squares) and gemcitabine (4-h incubation) 12 h prior to irradiation (circles); 0.01 μM gemcitabine in S40b (A) and MGH-U1 (B); 0.3 μM gemcitabine in S40b (C) and MGH-U1 (D). Dose modification factors (DMF) were calculated at IC₅₀ and were 1.4 (P<0.01), 1.1 (not significant), 1.2 (P<0.01) and 2.25 (P<0.001) for A, B, C and D, respectively.