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. 2004 Jan 20;90(2):343–347. doi: 10.1038/sj.bjc.6601469

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Copyright © 2003 Cancer Research UK

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Observed topotecan concentrations (data points) and model-predicted concentrations using the interoccasion variability option: data from one patient with minimal (−9%, A) or large (+104%, B) change of AUC after administration of the same dose at days 1 and 5 (1.5 mg m⁻²).