Table 4. Predictive performance of Bayesian estimation of AUC of topotecan given orally with limited sampling schedules tested in 15 patients (me mean relative prediction error, rmse root mean squared relative prediction error).

Sampling time intervals (hours postadministration)	Bias, me (%)	Precision, rmse (%)	Range of prediction error
1.5, 4, and 6 h	+2.3	9.3	−17.0–+45.2
1.5, and 6 h	+2.2	10.0	−17.0–+45.3