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. 2004 Jan 20;90(2):430–435. doi: 10.1038/sj.bjc.6601539

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Copyright © 2004 Cancer Research UK

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Representative immunohistochemical staining of antipanendothelial cell antigen in panels (A–D), with corresponding images of the DiOC₇ perfusion marker (green) superimposed over the EF5 hypoxia marker (orange), in panels (E–J). Intensely stained orange regions of (E–J) correspond to increased tumour hypoxia. MCF-7 vector is shown in (A) and (E), VEGF₁₂₁ in (B) and (F), VEGF₁₆₅ in (C) and (G), and FGF-1 in (D) and (H). Each of panels (A–H) are portions of the original 4 × 4 composite images taken with a × 20 objective, and the bar in panel (E) equals 100 μm. Panels (I) and (J) are entire 4 × 4 composites taken with a × 10 objective (bar in panel (I) equals 500 μm), illustrating the two general patterns of vascular configuration and hypoxia observed in VEGF₁₆₅ tumours. Peripheral vasculature with centralised hypoxia is shown in panel (I), and a more randomly distributed pattern of vasculature and hypoxia is shown in panel (J).