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. 2004 Jan 20;90(2):430–435. doi: 10.1038/sj.bjc.6601539

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Copyright © 2004 Cancer Research UK

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Effects of VEGF isoforms and FGF-1 on vascular spacing, % vascular area, and overall hypoxia. Data are presented as median distances (mean±s.e.) to the nearest total (A) or perfused (B) blood vessel, and increased median distances correspond to decreased vascular densities. An increased disparity between the total and perfused bars for a given tumour type indicates an increased proportion of nonfunctional vessels in that tumour. Data are averaged over four 4 × 4 image montages (64 fields) from each of 10 MCF-7 vectors (mean volume±s.e.m.=410±90 mm³), six VEGF₁₂₁ tumours (440±30)), five VEGF₁₆₅ tumours (570±80), and nine FGF-1 tumours (440±90). (C) Percentage vascular area for total (open bars) and perfused (filled bars) vessels. Asterisks denote statistically significant differences from vector controls. (D) Tumour hypoxia, as measured by overall EF5/Cy3 intensity (mean±s.e.), again averaged over four 4 × 4 image montages.