Skip to main content
. 1996 Nov 12;93(23):13351–13356. doi: 10.1073/pnas.93.23.13351

Figure 1.

Figure 1

Blocking effect of staurosporine and CBD on rebound potentiation of GABA-induced whole-cell current responses in cerebellar Purkinje neurons. (A) A conditioning depolarizing pulse (500 ms, from −70 mV to −10 mV) induced a long-lasting rebound potentiation of inward currents elicited by the application of 2 μM GABA (Top). Note the effective block of the potentiation by staurosporine (Middle) and CBD (Bottom). Records were taken 4 min before (left column) and 14 min after (right column) the conditioning depolarizing pulse. GABA was applied during the periods indicated by horizontal bars on top of each trace (10 s). (B) Changes in amplitudes of GABA-induced currents of Purkinje neurons for the staurosporine treated (Upper) (solid symbols, n = 6) and CBD injected (Lower) (solid symbols, n = 7) groups plotted against time after the conditioning pulse. The data from the same control group (open symbols, n = 9) are illustrated in both graphs. Data points are the mean ± SEM. Current amplitudes were normalized with respect to the mean value recorded 10 min prior to the depolarizing pulse.