Table 5. Dose intensity for phase I/II.
PDI (mg m−2 week−1) |
ADI (mg m−2 week−1) |
RDI (mg m−2 week−1) |
||||
---|---|---|---|---|---|---|
CDDP | PTX | CDDP | PTX | CDDP | PTX | |
Phase I | ||||||
Level 1 | 20.0 | 30.0 | 19.7 | 29.5 | 0.98 | 0.98 |
Level 2 | 20.0 | 37.5 | 18.5 | 32.6 | 0.93 | 0.87 |
Level 3 | 20.0 | 45.0 | 16.5 | 32.1 | 0.83 | 0.71 |
Level 4 | 20.0 | 52.5 | 17.8 | 36.7 | 0.89 | 0.70 |
Phase II | ||||||
20.0 | 52.5 | 19.2 | 41.6 | 0.96 | 0.79 |
PDI=projected dose intensity; ADI=actual dose intensity; RDI=relative dose intensity; CDDP=cisplatin; PTX=paclitaxel.