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. 2004 Mar 30;90(8):1479–1485. doi: 10.1038/sj.bjc.6601753

Table 2. Time from presentation to treatment for presenting breast cancer symptoms and other clinical variables.

    Days from presentation to treatment-geometric mean (95% CI)
 
N=1069 Number with symptom (%) With symptom Without symptom P-value
Breast lump 761 (71) 40 (37–43) 49 (44–55) 0.002
Breast pain 106 (10) 69 (54–88) 40 (38–42) <0.001
Nipple discharge – blood 9 (1) 168 (50–567) 42 (39–44) <0.001
Lymphadenopathy (axillary/supraclavicular) 58 (5) 32 (24–41) 43 (40–46) 0.026
Change in skin contour 134 (13) 26 (21–31) 45 (42–48) <0.001
Ulcerating or fungating lesion 26 (2) 17 (9–30) 43 (41–46) <0.001
Lump tethered to skin or underlying tissue 50 (5) 31 (23–42) 43 (40–46) 0.033
Bone pain 7 (1) 15 (6–37) 42 (40–45) 0.008
Skin discolouration 12 (1) 25 (13–48) 42 (40–45) 0.080
Fullness/lumpiness/asymmetry 9 (1) 75 (32–176) 42 (39–45) 0.092
         
Number of symptoms at presentation       <0.001
 0 225 (21) 36 (32–40)  
 1 494 (46) 53 (48–58)  
 2 248 (23) 37 (33–42)  
 3 or more 102 (10) 27 (22–34)  
       
Benign investigations in previous 5 years 292 (27) 49 (45–54) 40 (37–43) 0.002
Past history of benign breast disease 220 (21) 55 (46–64) 39 (37–42) <0.001

No differences (P>0.10) for nonblood stained nipple discharge, nipple distortion, nipple eczema, breast tenderness, discomfort or itch, breast inflammation, lymphoedema, or past history of anxiety or depression.