Table 3. Toxicity per patient (WHO grades) during the whole trial.

Toxicity	Per patient (89)			Per cycle (487)
	Grade 1–2	Grade 3	Grade 4	Grade 1–2	Grade 3	Grade 4
Anaemia	24 (27%)	5 (6%)		60 (12%)	7 (1%)
Thrombocytopenia	3 (3%)			3 (1%)
Nausea/vomiting	59 (66%)	3 (3%)	1 (1%)	184 (38%)	10 (2%)	3 (1%)
Diarrhoea	32 (36%)	10 (11%)	3 (3%)	94 (19%)	7 (1%)	6 (1%)
Stomatitis	6 (7%)	2 (2%)		8 (2%)	2 (1%)
Transaminases	26 (29%)	4 (4%)	2 (2%)	73 (15%)	7 (1%)	2 (1%)
Asthenia	27 (30%)	3 (3%)		109 (22%)	3 (1%)
Alopecia	31 (35%)	6 (7%)	3 (3%)	99 (20%)	14 (3%)	16 (3%)
Cholinergic syndrome	20 (22%)			44 (9%)