Table 1. Relation between history and time since diagnosis of cholelithiasis and colorectal cancer, among 3533 cases and 7062 controls (Italy, 1985-1996).
|
Men |
Women |
Total |
||||
|---|---|---|---|---|---|---|
| Risk factors | Cases : Controls | OR (95% CI)a | Cases : Controls | OR (95% CI)a | Cases : Controls | OR (95% CI)a |
| Colorectal cancer | ||||||
| History of cholelithiasis | ||||||
| No | 1858 : 3761 | 1b | 1325 : 2696 | 1b | 3183 : 6457 | 1b |
| Yes | 139 : 191 | 1.21 (0.95–1.54) | 211 : 414 | 0.95 (0.79–1.15) | 350 : 605 | 1.04 (0.90–1.21) |
| Time since diagnosis (years)c | ||||||
| <10 | 65 : 83 | 1.35 (0.95–1.92) | 74 : 144 | 0.97 (0.72–1.32) | 139 : 227 | 1.13 (0.90–1.42) |
| ⩾10 | 72 : 107 | 1.11 (0.81–1.52) | 137 : 270 | 0.96 (0.77–1.21) | 209 : 377 | 0.99 (0.82–1.19) |
| Colon cancer | ||||||
| History of cholelithiasis | ||||||
| No | 1103 : 3761 | 1b | 854 : 2696 | 1b | 1957 : 6457 | 1b |
| Yes | 83 : 191 | 1.24 (0.93–1.64) | 140 : 414 | 1.01 (0.81–1.26) | 223 : 605 | 1.08 (0.91–1.28) |
| Time since diagnosis (years)c | ||||||
| <10 | 41 : 83 | 1.47 (0.98–2.20) | 47 : 144 | 0.95 (0.67–1.36) | 88 : 227 | 1.16 (0.89–1.51) |
| ⩾10 | 40 : 107 | 1.03 (0.70–1.52) | 93 : 270 | 1.05 (0.80–1.36) | 133 : 377 | 1.02 (0.82–1.26) |
| Rectal cancer | ||||||
| History of cholelithiasis | ||||||
| No | 755 : 3761 | 1b | 471 : 2696 | 1b | 1226 : 6457 | 1b |
| Yes | 56 : 191 | 1.22 (0.88–1.69) | 71 : 414 | 0.93 (0.70–1.23) | 127 : 605 | 1.03 (0.83–1.27) |
| Time since diagnosis (years)c | ||||||
| <10 | 24 : 83 | 1.21 (0.75–1.97) | 27 : 144 | 1.03 (0.66–1.59) | 51 : 227 | 1.12 (0.81–1.54) |
| ⩾10 | 32 : 107 | 1.25 (0.82–1.90) | 44 : 270 | 0.88 (0.62–1.25) | 76 : 377 | 0.98 (0.75–1.28) |
a
Estimates from unconditional multiple logistic regression models, including terms for age, sex, study centre, education, cigarette smoking, alcohol drinking, BMI, meat consumption, total energy intake, history of diabetes, history of colorectal cancer in parents and siblings, menopausal status, use of oral contraceptives or hormone replacement therapy.
b
Reference category.
c
The sum does not correspond to the total number of subjects because of some missing values.