Table 3. Significant associations between LOH in 3p and markers of cancer progression, HR HPV and FHIT protein expression in 83 cancers: (a) Allelic loss in any region of 3p; (b) allelic loss at specific 3p loci for cancers informative at that locus calculated.

		Total		Risk marker positive		Statistical analysis
LOH site	Risk markers	No LOH	With LOH	No LOH	With LOH	P-value	OR	95% CI
(a) For all cancers
Anywhere on 3p	Differentiation – well	36	47	6	1		1.00
	– moderate	36	47	19	23		7.26
	– poor	36	47	11	23		12.55
						P-trend=0.018
	Depth ⩾10 mm	36	47	14	40	2P⩽0.001	8.980	2.848–29.751
(b) For informative cancers only
FHIT intron 3	Lympn node involvement	28	10	5	8	2P<0.001	18.400	2.382–206.044
FHIT intron 5 (SNP)	Depth ⩾10 mm	28	10	18	10	2P=0.038	a	1.305–a
FHIT intron 5 (MS)	Depth ⩾10 mm	54	20	31	20	2P<0.001	a	3.707–a
	Abnormal FHIT protein	54	20	25	16	2P=0.017	4.640	1.247–21.169

^aCannot be calculated.