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Dominant negative effect of the CLC-1 mutation P480L on wild-type CLC-2. (A) Current traces of an oocyte expressing CLC-2 (Left) or coexpressing CLC-2 and CLC-1P480L (Right). (B) Absolute current at the end of the test pulse to −140 mV (error bar = SEM, n = 9). Background current of noninjected oocytes was subtracted. RNA was coinjected at a 1:1 ratio, with a constant total amount of RNA.
