Table 5. Joint association of XPD-751, ERCC1-118, TS-3′UTR, and GSTP1-105 polymorphisms with survival and time to progression after 5-FU/oxaliplatin chemotherapy for disseminated colorectal cancer (multivariable analysis, stratified by ECOG).
|
Survival |
Progression |
||||
|---|---|---|---|---|---|
| Factors | No. of patients | Adj. relative riska | Adj. P-valuea | Adj. relative riskb | Adj. P-valueb |
| XPD-751 | 0.037 | ||||
| Lys/Lys | 40 | 1 | |||
| Lys/Gln | 53 | 1.50 (0.79, 2.87) | |||
| Gln/Gln | 13 | 3.33 (1.39, 7.99) | |||
| ERCC1-118 | 0.037 | ||||
| Favourable: C/C | 30 | 1 | |||
| Unfavourable | 76 | 2.05 (1.00, 4.20) | |||
| TS-3′UTR | 0.091 | 0.020 | |||
| Favourable: +6BP/+6BP | 37 | 1 | 1 | ||
| Unfavourable | 65 | 1.65 (0.91, 2.99) | 1.76 (1.08, 2.86) | ||
| Unknown | 4 | ||||
| GSTP1-105 | 0.072 | 0.018 | |||
| Val/Val | 10 | 1 | 1 | ||
| Ile/Val | 47 | 2.73 (0.88, 8.45) | 0.96 (0.42, 2.21) | ||
| Ile/Ile | 49 | 3.25 (1.04, 10.16) | 2.00 (0.85, 4.71) | ||
5-FU=5-fluorouracil; CI=confidence interval; GSTP=glutathione S-transferase; TS=thymidylate synthase; UTR=untranslated region.
a
Based on Cox's proportional-hazards model, stratified by ECOG, with all four genes included for survival.
b
Based on Cox's proportional-hazards model, stratified by ECOG, with TS-3′UTR and GSTP1-105 for time to progression.