Table 3. Relative risks for progression associated with combined marker status.

Variable	n	Relative risk	95% Confidence interval	P
p53/p16
Both normal	35	1.00
One altered	38	2.42	0.76–7.74	0.136
Both altered	5	14.45	3.10–67.35	0.001
p53/pRb
Both normal	32	1.00
One altered	34	1.88	0.56–6.25	0.304
Both altered	12	4.77	1.27–17.84	0.020
p16/pRb
Both normal	46	1.00
One altered	28	2.16	0.78–5.97	0.138
Both altered	4	8.98	1.81–44.44	0.007

Cox proportional hazards regression.