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. 2004 Jun 29;91(3):525–529. doi: 10.1038/sj.bjc.6602003

Table 5. Risk of breast cancer associated with oral steroid use.

  Cases (n=3708) Controls (n=20 000) Odds ratioa (95% CI)
Oral steroid use
 No useb 3370 18 090  
 Current use 132 820 0.83 (0.68, 1.02)
 Past use 206 1090 0.99 (0.84, 1.16)
       
Oral steroid duration
 0–0.9 years 93 560 0.84 (0.66, 1.07)
 1–1.9 years 9 59 0.88 (0.42, 1.80)
 2–3.9 years 17 82 1.09 (0.63, 1.90)
 4+ years 13 119 0.66 (0.36, 1.18)
       
Oral steroid dosec
 Low-medium 34 212 0.90 (0.62, 1.32)
 High 5 48 0.57 (0.22, 1.47)
       
Oral steroid indicationc
 Respiratory disease 13 70 1.13 (0.61, 2.08)
 Osteoarthritis 4 28 0.69 (0.23, 2.09)
 Polymyalgia rheumatica 8 57 0.77 (0.36, 1.65)
 Rheumatoid arthritis 9 57 0.96 (0.46, 1.99)
 Other 5 48 0.53 (0.20, 1.38)
a

Estimates are adjusted for age, calendar year, BMI, alcohol intake, smoking status, HRT, aspirin, NSAID, paracetamol, and prior benign breast disease using logistic regression.

b

Reference category.

c

Among current long-term users (1 or more years of treatment duration) vs nonusers.