Table 5. Risk of breast cancer associated with oral steroid use.
Cases (n=3708) | Controls (n=20 000) | Odds ratioa (95% CI) | |
---|---|---|---|
Oral steroid use | |||
No useb | 3370 | 18 090 | |
Current use | 132 | 820 | 0.83 (0.68, 1.02) |
Past use | 206 | 1090 | 0.99 (0.84, 1.16) |
Oral steroid duration | |||
0–0.9 years | 93 | 560 | 0.84 (0.66, 1.07) |
1–1.9 years | 9 | 59 | 0.88 (0.42, 1.80) |
2–3.9 years | 17 | 82 | 1.09 (0.63, 1.90) |
4+ years | 13 | 119 | 0.66 (0.36, 1.18) |
Oral steroid dosec | |||
Low-medium | 34 | 212 | 0.90 (0.62, 1.32) |
High | 5 | 48 | 0.57 (0.22, 1.47) |
Oral steroid indicationc | |||
Respiratory disease | 13 | 70 | 1.13 (0.61, 2.08) |
Osteoarthritis | 4 | 28 | 0.69 (0.23, 2.09) |
Polymyalgia rheumatica | 8 | 57 | 0.77 (0.36, 1.65) |
Rheumatoid arthritis | 9 | 57 | 0.96 (0.46, 1.99) |
Other | 5 | 48 | 0.53 (0.20, 1.38) |
Estimates are adjusted for age, calendar year, BMI, alcohol intake, smoking status, HRT, aspirin, NSAID, paracetamol, and prior benign breast disease using logistic regression.
Reference category.
Among current long-term users (1 or more years of treatment duration) vs nonusers.