Table 4. Diagnostic sensitivities of cytology, FISH, and the combination of both (cyto&FISH) in the whole series of effusions and major tumour entities (with ⩾10 effusions per tumour entity available).
| Tumour | Effusion (n) | Sensitivity cytology (%) | Sensitivity FISH (%) | P | Sensitivity Cyto&FISH (%) | P |
|---|---|---|---|---|---|---|
| All | 358 | 44.4 | 53.9 | 0.0001 | 60.9 | 0.0001 |
| Gynaecologica | 147 | 54.4 | 63.9 | 0.018 | 72.1 | 0.0001 |
| Breast | 104 | 50 | 63.1 | 0.031 | 71.2 | 0.0001 |
| Ovarian | 29 | 65.5 | 72.4 | 0.727 | 82.75 | 0.063 |
| Endometrial | 11 | 54.4 | 63.6 | 1 | 63.6 | 1 |
| Gastrointestinalb | 87 | 28.7 | 36.8 | 0.118 | 41.4 | 0.001 |
| Pancreatic | 34 | 38.2 | 52.9 | 0.125 | 55.9 | 0.031 |
| Hepatoma | 17 | 0 | 5.9 | 1 | 5.9 | 1 |
| Gastric | 14 | 50 | 64.3 | 0.625 | 71.4 | 0.25 |
| Colorectal | 11 | 18.2 | 18.2 | 1 | 27.3 | 1 |
| Lung | 71 | 54.9 | 71.8 | 0.008 | 76.1 | 0.0001 |
| UPCc | 17 | 35.3 | 47.1 | 0.687 | 58.8 | 0.125 |
| Haematologicald | 10 | 50 | 30 | 0.5 | 50 | 1 |
The P-values indicate significance levels for the comparison of FISH vs cytology (left column) and of cyto&FISH vs cytology (right column).
a
Gynaecologic tumours: breast (n=104), ovarian (29), endometrial (11), and cervical carcinoma (3).
b
Gastrointestinal tumours: pancreatic (34), hepatocellular (17), gastric (14), colorectal (11), cholangiocellular (9), and oesophageal carcinoma (2).
c
UPC, unknown primary cancer.
d
Haematological malignancies: non-Hodgkin's lymphoma (5), chronic myelogeneous leukaemia (2), Hodgkin's lymphoma (2), idiopathic myelofibrosis (1).