Table 2. Biomarkers according to expression of VEGF-C in stromal fibroblasts and tumour cells in resected NSCLC.
|
Expression of VEGF-C in |
||||||
|---|---|---|---|---|---|---|
|
Stromal macrophages |
Tumour cells |
|||||
| Negative | Positive | P-value | Low | High | P-value | |
| VEGF-A expression in tumour cells | ||||||
| Low | 35 (29.2) | 85 (70.8) | 1.000 | 59 (45.4) | 71 (54.6) | 0.026 |
| High | 20 (28.2) | 51 (71.8) | 22 (28.9) | 54 (71.1) | ||
| VEGF-C expression in stromal macrophages | ||||||
| Low | 36 (65.5) | 19 (34.5) | <0.001 | |||
| High | 36 (26.5) | 100 (73.5) | ||||
| VEGF-C expression in tumour cells | ||||||
| Negative | 36 (50.0) | 36 (50.0) | <0.001 | |||
| Positive | 19 (16.0) | 100 (84.0) | ||||
| Intratumoral microvessel density (IMVD) | ||||||
| CD34-IMVD (mean) | 191.1 | 183.3 | 0.623 | 175.3 | 189.9 | 0.306 |
| CD105-IMVD (mean) | 41.4 | 45.1 | 0.643 | 38.4 | 47.7 | 0.190 |
| p53 aberrant expression | ||||||
| Negative | 34 (31.2) | 75 (68.8) | 0.424 | 53 (44.9) | 65 (55.1) | 0.062 |
| Positive | 21 (25.6) | 61 (74.4) | 28 (31.8) | 60 (68.2) | ||
| Apoptotic index (mean) | 14.5 | 19.3 | 0.130 | 17.9 | 17.8 | 0.977 |
| Proliferative index (mean) | 36.6 | 48.3 | 0.008 | 43.2 | 47.6 | 0.281 |
Each figure shows the number of patients, and the percentage is shown in parentheses.