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. 2004 Jun 29;91(3):564–571. doi: 10.1038/sj.bjc.6601990

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Copyright © 2004 Cancer Research UK

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(A) Anti-uPAR HU277 immunoreaction of a high-grade DCIS. Myoepithelial cells show a strong staining (arrows) and tumour cells only a faint immunoreaction. Macrophages (arrowhead) are also positive. (B) Anti-uPAR IID7 immunoreaction of a high-grade DCIS. Myoepithelial cells show a strong immunoreaction (arrows) and tumour cells and endothelial cells are negative. Macrophages express the uPAR antigen (arrowhead). (C) Anti-PAI-1 immunoreaction of a high-grade DCIS. Tumour cells, endothelial cells (arrow) and stromal cells (arrowhead) are positive. The myoepithelial cell layer is absent; in corresponding tissue sections no MEs in this duct were observed using anti-calponin and anti-SMA antibodies. (D) Normal (nontumour) breast tissue stained for anti-uPAR IID7; MEs, epithelial cells and endothelial cells (arrow) show a strong immunoreaction, stromal cells (macrophages and fibroblasts) (arrowheads) are also positive. (E) Double staining of normal (nontumour) breast tissue stained for anti-uPAR IID7 (red colour) and anti-SMA (black colour); MEs show an immunoreaction for both anti-uPAR and anti-SMA. (F) Normal (nontumour) breast tissue stained for anti-PAI-1; in both images, the ducts (MEs and epithelial cells) are negative, whereas endothelial cells (arrows) and stromal cells (arrowheads) show positive immunoreactions. (G, H) Nonisotopic in situ hybridisation using fluorescein-labelled oligodeoxynucleotides complementary to PAI-1 mRNA in a non-high-grade DCIS with necrosis; (G) antisense probe: a distinct reaction in MEs (arrows) and tumour cells, stromal cells and endothelial cells (arrowhead) is observed; (H) no reaction is seen with the sense probe.