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| Toxicity | CTC grade | Dose level 1 (23 patients) | Dose level 2 (nine patients) | |
|---|---|---|---|---|
| Haematological | Thrombocytopenia | 3 | 10 | |
| 4 | 2 | 3 (DLT) | ||
| Neutropenia | 3 | 9 | ||
| 4 | 2 (DLT) | |||
| Anaemia | 3 | 4 | ||
| 4 | ||||
| Gastrointestinal | Perforation | 4 | 1 | |
| Haemorrhage | 4 | 1 | ||
| Other | 4 | 1 | ||
| Nausea | 2 | 4 | ||
| 3 | 2 | |||
| Neurological | 2 | 1 |
