Table 1. Serum CYFRA 21-1, CEA, and CA 15-3 titres of 160 patients with primary breast cancer according to stage.
| Variables | CYFRA 21-1 (ng ml−1) | CEA (ng ml−1) | CA 15-3 (U ml−1) |
|---|---|---|---|
| Cutoff value | 2.0 | 6.5 | 30 |
| UICC staging | Median (range) | Median (range) | Median (range) |
| 0 (n=3) | 0.8 (0.2–1.8) | 1.4 (1.0–3.6) | 11.3 (6.8–12.3) |
| I (n=46) | 1.3 (0.3–3.0) | 2.8 (0.8–9.2) | 12.6 (6.5–30.8) |
| II (n=62) | 1.4 (0.5–6.2) | 3.0 (0.9–29.3) | 16.2 (5.7–141) |
| III (n=37) | 1.3 (0.5–23) | 2.4 (0.6–48.3) | 15.9 (5.4–165) |
| IV (n=12) | 4.4 (1.2–122) | 4.7 (1.1–24.7) | 76.3 (14.2–4470) |
| Kruskal–Wallis test | P<0.0001 | P=0.1285 | P<0.0001 |
| Mann–Whitney U-test | P-value | P-value | P-value |
| Stage 0 vs I–IV | 0.2568 | 0.1550 | 0.0691 |
| Stage 0–I vs II–IV | 0.0046 | 0.0808 | 0.0001 |
| Stage 0–II vs III–IV | 0.0003 | 0.5038 | 0.0001 |
| Stage 0–III vs IV | <0.0001 | 0.0676 | <0.0001 |
CEA=carcinoembryonic antigen; CA=carbohydrate antigen.
UICC=Union Internationale Contre le Cancer.