Table 1. Enzyme and cellular potency of VEGFR2 kinase inhibitors.

IC₅₀ of various small molecules were determined against human VEGFR2 kinase as well as HUVEC grown in presence of VEGF or bFGF as described in Materials and Methods.

HUVEC=human umbilical vein endothelial cells; VEGFR=vascular endothelial growth factor (VEGF) receptor; IC=inhibitory concentration.