Table 3. Ets-1 mRNA and protein expression in different subsets of primary breast carcinomas.
|
Ets-1 mRNA |
Ets-1 p52 |
Ets-1 p51 |
Ets-1 p42 |
Ets-1 p33 |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| n | No. Pos (%) | n | No. Pos. (%) | n | No. Pos. (%) | n | No. Pos. (%) | n | No. Pos. (%) | |
| Nodal status | ||||||||||
| Negative | 80 | 62 (78) | 32 | 27 (84) | 32 | 18 (56) | 32 | 6 (19) | 32 | 22 (69) |
| Positive | 89 | 63 (71) | 39 | 33 (85) | 39 | 22 (56) | 39 | 1 (2.5) | 39 | 26 (67) |
| Unknown | 10 | 7 | 7 | 7 | 7 | |||||
| Tumour size | ||||||||||
| T1 (⩽2 cm) | 45 | 34 (76) | 17 | 15 (88) | 17 | 14 (82) | 17 | 1 (6) | 17 | 15 (88) |
| T2 (2–5 cm) | 91 | 68 (75) | 38 | 30 (79) | 38 | 16 (42) | 38 | 4 (11) | 38 | 21 (55) |
| T3–4 (⩾5 cm) | 29 | 18 (62) | 18 | 15 (83) | 18 | 10 (56) | 18 | 1 (6) | 18 | 11 (61) |
| Unknown | 14 | 5 | 5 | 5 | 5 | |||||
| Histology type | ||||||||||
| Ductal (D) | 133 | 98 (70) | 61 | 53 (87) | 61 | 31 (51) | 61 | 6 (9.8) | 61 | 40 (66) |
| Lobular (L) | 27 | 20 (74) | 7 | 6 (86) | 7 | 6 (86) | 7 | 1 (14) | 7 | 5 (71) |
| D & L | 10 | 7 (70) | 6 | 2 (33) | 6 | 4 (67) | 6 | 0 (0) | 6 | 4 (44) |
| Unknown | 9 | 4 | 4 | 4 | 4 | |||||
| ER statusa | ||||||||||
| Negative | 50 | 37 (74) | 20 | 15 (75) | 20 | 10 (50) | 20 | 1 (5) | 20 | 13 (65) |
| Positive | 128 | 93 (73) | 56 | 49 (88) | 56 | 33 (59) | 56 | 6 (11) | 56 | 37 (66) |
| Unknown | 1 | 2 | 2 | 2 | 2 | |||||
| PR statusb | ||||||||||
| Negative | 73 | 53 (73) | 36 | 30 (83) | 36 | 16 (44) | 36 | 3 (8) | 36 | 26 (72) |
| Positive | 77 | 93 (73) | 35 | 30 (86) | 35 | 23 (66) | 35 | 3 (9) | 35 | 20 (57) |
| Unknown | 29 | 7 | 7 | 7 | 7 | |||||
ER=oestrogen receptor. PR=progesterone receptor.
a
Cutoff point=200 fmol g−1 of wet weight tissue.
b
Cutoff point=1000 fmol g−1 of wet weight tissue.