Table 1. Modified classification of NSCLC based on growth patterns.

Growth pattern	Determination	Vascularisation at interface	Destruction of lung parenchyma at interface	Formation of stroma at interface	Corresponding growth pattern according to Pezzella et al (1997)
Destructive (angiogenic)	At the interface	Only newly formed vessels	Destruction	Present	Diffuse and basal
Papillary (intermediate)	At the interface	Newly formed vessels admixed with pre-existing vessels	No destruction	Present	Papillary
Alveolar (nonangiogenic)	At the interface	Pre-existing vessels	No destruction	Absent	Alveolar (entirely alveolar)+partially alveolar (basal, diffuse)