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. 2004 Sep 14;91(8):1453–1458. doi: 10.1038/sj.bjc.6602169

Table 2. Incidences of grade 3 or 4 toxicities.

Toxicities Whole group (n=339) <70 years (n=267) ⩾70 years (n=72) Male (n=201) Female (n=138) PS 0–1 (n=295) PS 2–3 (n=41) Previous RT (n=51) No previous RT (n=288)
Anaemia 17 (5%) 15 (6%) 2 (3%) 10 (5%) 7 (5%) 16 (5%) 1 (2%) 3 (6%) 14 (5%)
Neutropenia 83 (24%) 58 (22%) 25 (35%) 61 (30%) 22 (16%) 72 (24%) 11 (27%) 12 (24%) 71 (25%)
Thrombocytopenia 12 (4%) 8 (3%) 4 (6%) 7 (3%) 5 (4%) 10 (3%) 2 (5%) 3 (6%) 9 (3%)
Febrile neutropenia 4 (1%) 2 (0.7%) 2 (3%) 3 (1%) 1 (0.7%) 3 (1%) 1 (2%) 0 (0%) 4 (1%)
Diarrhoea 53 (16%) 42 (16%) 11 (15%) 35 (17%) 18 (13%) 43 (15%) 9a (22%) 12 (24%) 41 (14%)
Nausea and vomiting 18 (5%) 15 (6%) 3 (4%) 10 (5%) 8 (6%) 17 (6%) 1 (2%) 2 (4%) 16 (6%)
Infection 20 (6%) 18 (7%) 2 (3%) 14 (7%) 6 (4%) 17 (6%) 3 (7%) 4 (8%) 16 (6%)
Fever 13 (4%) 12 (5%) 1 (1%) 9 (5%) 4 (3%) 11 (4%) 2 (5%) 1 (2%) 12 (4%)
Lethargy 72 (21%) 57 (21%) 15 (21%) 45 (22%) 27 (20%) 60 (20%) 11 (27%) 10 (20%) 62 (22%)

PS: performance status. RT: radiotherapy.

a

One patient with grade 3–4 diarrhoea had unknown baseline performance status.