Table 2. Incidences of grade 3 or 4 toxicities.
| Toxicities | Whole group (n=339) | <70 years (n=267) | ⩾70 years (n=72) | Male (n=201) | Female (n=138) | PS 0–1 (n=295) | PS 2–3 (n=41) | Previous RT (n=51) | No previous RT (n=288) |
|---|---|---|---|---|---|---|---|---|---|
| Anaemia | 17 (5%) | 15 (6%) | 2 (3%) | 10 (5%) | 7 (5%) | 16 (5%) | 1 (2%) | 3 (6%) | 14 (5%) |
| Neutropenia | 83 (24%) | 58 (22%) | 25 (35%) | 61 (30%) | 22 (16%) | 72 (24%) | 11 (27%) | 12 (24%) | 71 (25%) |
| Thrombocytopenia | 12 (4%) | 8 (3%) | 4 (6%) | 7 (3%) | 5 (4%) | 10 (3%) | 2 (5%) | 3 (6%) | 9 (3%) |
| Febrile neutropenia | 4 (1%) | 2 (0.7%) | 2 (3%) | 3 (1%) | 1 (0.7%) | 3 (1%) | 1 (2%) | 0 (0%) | 4 (1%) |
| Diarrhoea | 53 (16%) | 42 (16%) | 11 (15%) | 35 (17%) | 18 (13%) | 43 (15%) | 9a (22%) | 12 (24%) | 41 (14%) |
| Nausea and vomiting | 18 (5%) | 15 (6%) | 3 (4%) | 10 (5%) | 8 (6%) | 17 (6%) | 1 (2%) | 2 (4%) | 16 (6%) |
| Infection | 20 (6%) | 18 (7%) | 2 (3%) | 14 (7%) | 6 (4%) | 17 (6%) | 3 (7%) | 4 (8%) | 16 (6%) |
| Fever | 13 (4%) | 12 (5%) | 1 (1%) | 9 (5%) | 4 (3%) | 11 (4%) | 2 (5%) | 1 (2%) | 12 (4%) |
| Lethargy | 72 (21%) | 57 (21%) | 15 (21%) | 45 (22%) | 27 (20%) | 60 (20%) | 11 (27%) | 10 (20%) | 62 (22%) |
PS: performance status. RT: radiotherapy.
a
One patient with grade 3–4 diarrhoea had unknown baseline performance status.