Table 7. Nonhaematologic toxicity.

	Arm A		Arm B		Arm C		Arm D
	All grades	Grade 3–4	All grades	Grade 3–4	All grades	Grade 3–4	All grades	Grade 3–4
Toxicity type	% of patients
Gastrointestinal origin
Diarrhoea	88	10	76	24	74	13	77	25
Nausea	73	15	73	5	65	9	80	23
Vomiting	54	10	57	3	50	9	59	16
Gastrointestinal pain	17	2	16	3	17	2	23	2
Anorexia	12	—	14	—	17	—	34	5
Other
Fatigue	51	7	38	3	61	4	52	7
Fever in absence of infection	12	2	19	-	15	4	16	—
Infection	7	2	11	5	11	—	11	7
Cholinergic syndrome	68a	—	41a	—	61a	2	7a	—
Alopecia	71b	—	43	—	67b	—	34b	—

Toxicity is expressed as % of patients with adverse events possibly or probably related to study drug medication; worst grade during study. N=41 in arm A, 37 in arm B, 46 in arm C and 44 in arm D.

^aArm D is significantly different from arm A, B and C (P⩽0.001).

^bArm D is significantly different from arm A and C (P<0.001).