Table 3. Predicted BRCA1/2 carrier probabilities for a breast cancer case whose mother developed breast cancer.
Age at onset of breast cancer for mother (years) |
|||||
---|---|---|---|---|---|
Index age at onset (years) | 30 | 40 | 50 | 60 | 70 |
30 | |||||
BRCA1 | 0.400 (0.566) | 0.223 (0.415) | 0.075 (0.244) | 0.045 (0.103) | 0.042 (0.049) |
BRCA2 | 0.318 (0.036) | 0.221 (0.034) | 0.196 (0.037) | 0.153 (0.030) | 0.102 (0.020) |
40 | |||||
BRCA1 | 0.212 (0.407) | 0.087 (0.270) | 0.025 (0.144) | 0.014 (0.056) | 0.013 (0.025) |
BRCA2 | 0.211 (0.033) | 0.107 (0.028) | 0.082 (0.027) | 0.062 (0.021) | 0.041 (0.013) |
50 | |||||
BRCA1 | 0.056 (0.228) | 0.020 (0.137) | 0.006 (0.067) | 0.003 (0.024) | 0.003 (0.011) |
BRCA2 | 0.180 (0.035) | 0.080 (0.027) | 0.061 (0.024) | 0.047 (0.018) | 0.032 (0.011) |
60 | |||||
BRCA1 | 0.023 (0.079) | 0.008 (0.043) | 0.002 (0.020) | 0.001 (0.007) | 0.001 (0.003) |
BRCA2 | 0.134 (0.028) | 0.058 (0.020) | 0.045 (0.017) | 0.036 (0.012) | 0.025 (0.007) |
70 | |||||
BRCA1 | 0.019 (0.022) | 0.006 (0.011) | 0.002 (0.005) | 0.001 (0.001) | 0.001 (0.000) |
BRCA2 | 0.080 (0.016) | 0.034 (0.011) | 0.028 (0.009) | 0.024 (0.006) | 0.017 (0.004) |
Corresponding probabilities using BRCAPRO within parentheses.