Table 2. Serum concentrations of IGF-I, IGF-II, IGFBP-3 and the molar IGF-I/ IGFBP-3 ratio by smoking status in men and women.
|
Mean concentrations (s.d.) |
||||||
|---|---|---|---|---|---|---|
| IGF-I (ng ml−1) | IGF-II (ng ml−1) | IGFBP-3 (ng ml−1) | IGF-I/IGFBP-3 | |||
| Men | ||||||
| Smoking status | ||||||
| Never smoker | 200 (62) | 833 (181) | 3192 (549) | 0.225 (0.053) | ||
| Former smoker | 189 (73) | 834 (205) | 3099 (657) | 0.219 (0.059) | ||
| Current smoker | 183 (67) | 806 (192) | 2903 (615) | 0.229 (0.061) | ||
| P (1-ANOVA) | 0.32 | 0.71 | 0.04 | 0.57 | ||
| Women | ||||||
| HRT within 6 months | ||||||
| No (n=127) | 178 (52) | 883 (187) | 3355 (588) | 0.198 (0.050) | ||
| Yes (n=83) | 156 (50) | 877 (189) | 3134 (636) | 0.186 (0.048) | ||
| P (Student's t-test) | 0.003 | 0.81 | 0.01 | 0.09 | ||
| Smoking status | No HRT | HRT | No HRT | HRT | ||
| Never smoker | 181 (56) | 163 (54) | 892 (194) | 3368 (611) | 3142 (603) | 0.198 (0.051) |
| Former smoker | 176 (52) | 149 (37) | 868 (174) | 3388 (611) | 3145 (607) | 0.188 (0.046) |
| Current smoker | 172 (44) | 151 (55) | 868 (190) | 3258 (483) | 3101 (774) | 0.191 (0.50) |
| P (1-ANOVA) | 0.77 | 0.51 | 0.65 | 0.69 | 0.97 | 0.43 |
s.d.=standard deviation. HRT=hormonal replacement therapy. Current HRT use defined as within the past 6 months.
Molar ratio conversion: 1 ng ml−1 is 0.130 nmol l−1 for IGF-I and 0.036 nmol l−1 for IGFBP-3.