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. 2004 Oct 12;91(9):1703–1710. doi: 10.1038/sj.bjc.6602181

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Copyright © 2004 Cancer Research UK

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Clodronate stimulated ER transcriptional activity. MVLN cells were incubated in SFM for 24 h with 10⁻⁴ M clodronate (Clod), 10⁻¹⁰ M E₂, 10⁻⁷ M 4-OH-TAM (TAM), 10⁻⁷ M fulvestrant (ICI), combination of Clod or E₂ with antioestrogens, Clod+E₂ or vehicle (control) in SFM. Luciferase activities were normalised with protein levels. Data are given as percentages of control values (mean±s.d.). Experiments were performed four times in replicate (n=8). ^*ANOVA, P<0.05 vs control.