Table 1. Illustration of the cumulative incidence of haematologic malignancy (HM) for the Fanconi anaemia (FA) data set using the Kaplan–Meier method.
(a) A subset of FA patientsa | |||||
---|---|---|---|---|---|
Patient number | Follow-up time | Status | HM status | ||
1 | 0.003 | Dead | C | ||
2 | 0.003 | Dead | C | ||
… | |||||
21 | 4 | HM | E | ||
… | |||||
744 | 495 | HM | E | ||
745 | 498 | HM | E | ||
746 | 509 | Alive | C | ||
747 | 522 | Dead | C | ||
748 | 538 | Alive | C | ||
749 | 544 | HM | E | ||
750 | 546 | HM | E | ||
751 | 566 | Alive | C | ||
752 | 572 | Alive | C | ||
753 | 582 | HM | E | ||
754 | 587 | Dead | C | ||
755 | 599 | Alive | C | ||
(b) Kaplan–Meier survival probability estimatesb | |||||
Time interval (tj) | # at risk (nj) | # of events (dj) | Survival probability ((nj−dj)/nj) (%) | Overall survival (S(tj)) (%) | Incidence 1−S(tj) |
0– | 755 | 0 | 100 | 100 | 0 |
4– | 735 | 1 | 99.9 | 99.9 | 0.1 |
… | 44.9 | 55.1 | |||
495– | 12 | 1 | 91.7 | 41.2 | 58.8 |
498– | 11 | 1 | 90.9 | 37.5 | 62.5 |
544– | 7 | 1 | 85.7 | 32.1 | 67.9 |
546– | 6 | 1 | 83.3 | 26.8 | 73.2 |
582– | 3 | 1 | 66.7 | 17.8 | 82.2 |
HM=haematologic malignancy; C=censored; E=event.
The follow-up time (in months), event status (affected with HM, dead or alive) and HM status (event if patient has HM, censored otherwise).
Kaplan–Meier survival probability estimates for the subset of the FA patients listed in (a). Column 1 gives the event times (in months). Column 2 shows the number of individuals at risk before that event time. Column 3 is the number of patients diagnosed with HM at that time. Column 4 is the estimated survival probability between that event time and the next. Column 5 provides the overall survival probability using the Kaplan–Meier method. Column 6 gives the cumulative incidence of HM.