Table 1. Tumour and abnormality incidence and tumour spectrum.

					Histological tumour types
Genotype	na	Age (months)	Incidence of tumours and/or abnormal lesions (% of animals)	Intestinal lesions (% of animals)	Forestomach papilloma	Lymphoid malignancies	Other neoplasms
Fhit (+/+)	26	12–20	8 (30%)	0	3 (12%)	3 (12%)	1 hepatocellular carcinoma
						2 lymphomas (1 B-cell lymphoma)	1 periosis hepatis
						1 lymphocyte infiltration	1 endometrial hyperplasia
Fhit (+/–)	90	12–20	54 (60%)b	19 (21%)	22 (24%)	23 (26%)	1 hepatocellular carcinoma
				6 small intestinal polyps		18 lymphomas (16 B-cell lymphomas)	1 hepatocellular adenoma
				5 fused villi		5 lymphocyte infiltrations	1 liver hemangioma
				8 swollen crypts			2 endometrial hyperplasia
							1 uterine leiomyoma
							1 lung adenoma
							1 Leydig cell tumour
							1 dermoid cyst
Fhit (–/–)	26	12–20	20 (77%)b	7c (27%)	6 (23%)	11 (42%)	2 hepatocellular carcinomas
				4 small intestinal polyps		9 lymphomas (6 B-cell lymphomas)	2 endometrial hyperplasia
				3 fused villi		2 lymphocyte infiltrations	1 GISTd
				1 swollen crypts

^aNumber of animals.

^bP<0.05 compared to wild-type controls by chi-squared test.

^cOne of these mice contained a small intestinal polyp and a fused villi. The other mice contained only one lesion per mouse.

^dGastrointestinal stromal tumour.