Table 2.

Ectopic expression of eQTL candidate genes modulates metastasis-predictive ECM gene expression

	Chromosome 7 ECM eQTL candidate gene		Chromosome 17 ECM eQTL candidate genes
	Ndn		Luc7l		Pi16
Gene expression tested by qPCR	Log10 expression ratio vs. Mvt1/β-Gal	S.D.	Log10 expression ratio vs. Mvt1/β-Gal	S.D.	Log10 expression ratio vs. Mvt1/β-Gal	S.D.
Col1a1	0.32	0.13	1.13	0.14	0.62	0.12
Col1a2	2.93	0.57	0.24	0.65	0.62	0.13
Col3a1	−1.17	0.31	−1.55	0.45	−1.11	0.73
Col5a3	0.94	0.31	−1.27	0.78	0.26	0.64
Col6a2	−1.29	0.60	−1.42	0.56	−0.82	0.50
Fbn1	−1.12	0.21	−0.69	0.36	−0.71	0.26
Fbln2	−0.81	0.33	0.23	0.80	0.44	0.46
Mfap5	−1.01	0.26	−1.11	0.14	−1.50	0.73
Mmp2	*	*	*	*	*	*
Nid1	−0.76	0.31	−0.27	0.11	−0.46	0.28
Serpinf1	−0.09	0.29	−0.57	0.06	−0.16	0.25
Serping1	0.02	0.33	−0.10	0.29	−0.21	0.14
Chromosome 18 ECM eQTL candidate genes
	Centd3			Csf1r
Gene Expression Tested by qPCR	Log10 expression ratio vs. Mvt1/β-Gal	S.D.		Log10 expression ratio vs. Mvt1/β-Gal	S.D.
Col1a1	0.94	0.16		−0.02	0.65
Col1a2	−0.01	0.22		−0.51	0.17
Col3a1	−1.60	0.68		−1.40	1.04
Col5a3	−1.83	1.26		−1.02	0.65
Col6a2	−0.59	1.23		−0.69	1.00
Fbn1	−0.46	0.48		−0.72	0.37
Fbln2	0.19	0.40		1.68	1.67
Mfap5	−1.16	0.60		−0.78	0.70
Mmp2	*	*		*	*
Nid1	−0.19	0.14		−0.24	0.05
Serpinf1	−0.28	0.16		−0.10	0.21
Serping1	1.10	0.77		0.51	0.60

^*Expression too low to quantify

† Statistically significant at the P≤0.05 level (bold typeface)