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. Author manuscript; available in PMC: 2008 Jun 4.
Published in final edited form as: J Immunol. 2002 Nov 15;169(10):6036–6047. doi: 10.4049/jimmunol.169.10.6036

Table III.

Dose response of C7 and C8 T cells to peptides from TRP-1 and TRP-2

Peptide
(μg/ml)		 IFN-γ (pg/ml)
QB1a GC1 A1 B1 E1 E4 F4
C7 T Cell Response
50 1652 1272 2628 1984 480 684 336
12 308 464 496 508 316 228 192
3.1 236 324 240 324 264 156 56
0.8 64 160 100 88 108 8 8
0.2 8 116 48 8 60 8 8
C8 T Cell Response
50 888 680 1840 5540 785 940 610
12 610 285 826 932 353 330 45
3.1 46 32 62 81 48 31 <8
0.8 <8 <8 <8 31 12 14 <8
0.2 <8 <8 <8 <8 <8 <8 <8
a

Autologous EBV B cells (2 × 105) were incubated with peptides for 2 h, followed by incubation with 2 × 104 C6 or C7 T cells, and IFN-γ release was determined 18–24 h later. Target cells were incubated with the following peptides, with the amino acid positions indicated in parentheses, from either TRP-2, QB1-ALPYWNFATGRRNECDVCTDQ (241–260), GC1-LQR LIGNESFALPYWNFATG (231–250), A1-ALPYWNFATGRNECDV (241–256), E1-NESFALPWNFATG (237–250), F4-AL PYWNFATG (241–250), or TPR-1, B1-SLPYWNFATGKNVCDI (245–254) and E4-SLPYWNFATG (245–254).