Table 1. Characteristics of the study population.
|
Ovarian cancer |
Borderline tumour |
|||
|---|---|---|---|---|
| Cases (n=478) | Controls (n=1421) | Cases (n=190) | Controls (n=568) | |
| Age at diagnosis (years)a | ||||
| Median (range) | 52 (33–78) | 51 (30–77) | 49 (26–76) | 49 (23–78) |
| Time between serum sampling and diagnosis (years)a | ||||
| Median (range) | 7.2 (0.1–26) | 7.2 (−0.5–26) | 7.1 (0.1–23) | 7.2 (−0.5–23) |
| Histology | ||||
| Serous | 251 (53%) | 96 (51%) | ||
| Mucinous | 28 (6%) | 86 (45%) | ||
| Endometrioid | 76 (16%) | 3 (2%) | ||
| Clear cell | 53 (11%) | |||
| Mixed epithelial | 24 (5%) | |||
| Undifferentiated | 20 (4%) | |||
| Granulosa cell | 15 (3%) | |||
| Other | 11 (2%) | 5 (3%) | ||
| BRCA1 mutations | ||||
| 816delGT | 1 | 0 | 0 | 0 |
| 1135insA | 5 | 1 | 0 | 0 |
| 1675delA | 8 | 1 | 0 | 0 |
| 3347delAG | 5 | 0 | 0 | 0 |
| Any mutation | 19 | 2 | 0 | 0 |
| CA 125 | ||||
| Median (range) | 14 (0–100) | 10 (0–100) | 15 (0–100) | 11 (0–100) |
| No. positive (>35 U ml−1) | 71 | 79 | 35 | 45 |
a
For controls, the date of diagnosis for the belonging case was used.