Table 5. Recent studies of single-agent chemotherapy for biliary tract cancer.

		No. of patients
Author	Regimen	Total	Gallbladder Ca.	Response rate (%)	MST (months)
Takada et al (1994)	5-FU	18	10	0	NA
Taal et al (1993)	Mitomycin C	30	13	10	4.5
Okada et al (1994)	Cisplatin	13	6	8	5.5
Jones et al (1996)	Paclitaxel	15	4	0	NA
Pazdur et al (1999)	Docetaxel	17	0	0	NA
Papakostas et al (2001)	Docetaxel	25	16	20	8
Sanz-Altamira et al (2001)	Irinotecan	25	10	8	10
Mezger et al (1998)	Gemcitabine	13	4	8	NA
Raderer et al (1999)	Gemcitabine	19	5	16	6.5
Penz et al (2001)	Gemcitabinea	32	10	22	11.5
Kubicka et al (2001)	Gemcitabine	23	0	30	9.3
Gallardo et al (2001)	Gemcitabine	26	26	36	7
Gebbia et al (2001)	Gemcitabine	18	12	22	8
Tsavaris et al (2004)	Gemcitabine	30	14	30	14
Current study	S-1	19	16	21	8.3

5-FU: 5-fluorouracil; MST: median survival time; NA: not available.

^aBiweekly.