Table 3. Adverse event.

	Grade 2		Grade 3		Grade 4
Toxicity	No (%) patients	% cycles	No (%) patients	% cycles	No (%) patients	% cycles
Neutropenia	4 (19)	23	9 (43)	20	3 (14)	5
Thrombocytopenia	0	2	4 (19)	6	1 (5)	1
Anaemia	10 (38)	14	2 (10)	2	0	0
Infection	6 (29)	16	7 (33)	9	0	0
Palmar-plantar erythema	5 (24)	9	4 (19)	5	0	0
Diarrhoea	2 (10)	2	3 (14)	5	0	0
Nausea and vomiting	6 (29)	7	1 (5)	1	0	0
Lethargy	5 (24)	8	2 (10)	4	0	0
Thromboembolism	0	0	1 (5)	1	2 (10)	2
Skin rash	4 (19)	6	1 (5)	2	1 (5)	1
Haemorrhage	2 (10)	4	1 (5)	1	0	0
Dyspnoea	6 (29)	12	1 (5)	1	0	0
Mood alteration	0	1	1 (5)	1	0	0
Renal impairment	1 (5)	1	2 (10)	2	0	0
Hepatic dysfunction	1 (5)	2	1 (5)	1	0	0