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. 2004 Oct 26;91(10):1821–1828. doi: 10.1038/sj.bjc.6602212

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Copyright © 2004 Cancer Research UK

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Effect of ATRA, 4HPR and redox modulators on ceramide production. MCF-7 cells were grown to approximately 70% confluence and ceramide production was measured (see Materials and Methods) during a subsequent 24 h period: (A) in the absence or presence of ATRA (2, 5 μM) or 4HPR (2, 5 μM); (B) in the absence or presence of 5 μM 4HPR, 0.5 mM H₂O₂, 10 mM N-acetylcysteine (NAC) or 5 μM TGZ. Total ceramide production is expressed as a percentage of control values determined in the absence of 4HPR. Control ceramide levels were calculated to be 0.53±0.04% of total ³H-labelled lipid. (A) ^*P<0.02 for stimulation; (B) ^*P<0.02 for stimulation; ^**P<0.05 for reduction of this stimulation.