Table 1. Comparison of chemosensitivity in the MDA-MB-435S-F cell line and its paclitaxel selected variants.

	IC50 (ng ml−1)
Drug	MDA-MB- 435S-F	MDA-MB-435S- F/Taxol-10p	Fold resistance of MDA-MB-435S- F/Taxol-10p	MDA-MB-435S- F/Taxol-10p4p	Fold resistance of MDA-MB-435S- F/Taxol-10p4p
Doxorubicin	271±3	242±21	0.89	456±20**	1.68
Paclitaxel	28.3±1.52	259±3**	9.15	900±40**	31.80
Carboplatin	41 300±1500	54 300±5100*	1.31	33 000±3400	0.79
Docetaxel	3.33±0.37	12.23±0.37**	3.67	62.4±1.3**	18.73
VP-16	1844±77	2225±152	1.20	1740±17	0.94
5-Fluorouracil	7430±680	3500±170**	0.47	6830±600	0.91
Vincristine	12.9±1.3	74.6±0.5**	5.78	176±56**	13.64

^aThe IC₅₀ values are the mean of a minimum of three repeat experiments.

^*P<0.05, Student's t-test.

^**P<0.005, Student's t-test.