Table 2. Comparison of chemosensitivity in the MDA-MB-435S-F cell line and its doxorubicin selected variants.

	IC50 (ng ml−1)
Drug	MDA-MB- 435S-F	MDA-MB-435S- F/Adr-10p	Fold resistance of MDA-MB-435S-F/Adr-10p	MDA-MB-435S- F/Adr-10p10p	Fold resistance of MDA-MB-435S-F/Adr-10p10p
Doxorubicin	271±3	316±15	1.16	381±11.54**	1.40
Paclitaxel	28.3±1.52	20.3±2.1*	0.71	17.6±0.2*	0.62
Carboplatin	41 300±1500	37 600±1150	0.91	24 600±1520*	0.59
Docetaxel	3.33±0.37	3.76±0.20	1.12	4.76±0.152*	1.42
VP-16	1844±77	2663±148**	1.44	3785±79**	2.05
5-Fluorouracil	7430±680	3360±400*	0.45	3430±50*	0.46
Vincristine	12.9±1.3	6.9±0.69**	0.53	32.1±2.5**	1.61

^aThe IC₅₀ values are the mean of a minimum of three repeat experiments.

^*P<0.05, Student's t-test.

^**P<0.005, Student's t-test.