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. 2007 Dec 17;104(52):20764–20769. doi: 10.1073/pnas.0705659105

Fig. 2.

Fig. 2.

Crystal structure of AKR1B10 complexed with NADP+ and tolrestat. (A) View from the top of the (α/β)8 barrel. The catalytic site is located in the center of the barrel. (B) View of the (α/β)8 barrel after rotating 90°. Cofactor approaches the catalytic site from one side of the barrel, and tolrestat enters the barrel from the upper face. (C) LIGPLOT (32) describing interactions of the tolrestat molecule in the AKR1B10–NADP+–tolrestat complex. (D) LIGPLOT of tolrestat in the AKR1B1–NADP+–tolrestat complex.