Figure 3.
Effects of the group III mGluR antagonist MSOP on AMN082-induced changes in NAc GABA and glutamate. Local perfusion of MSOP (100 μM) into the NAc completely blocked AMN082 (10 mg/kg)-induced decreases in GABA (Panel A) and increases in glutamate (Panel B), while MSOP alone had no effect on NAc GABA and glutamate. *p<0.05, **p<0.01, ***p<0.001, compared with the baseline of each treatment group.