Table 2.
5HT1A receptor BP [mean (SD)] measured with [11C]WAY100635 derived with 90 minutes of Logan graphical analysis, corrected for partial volume effects.
| PP-C | PP-D | % DIFF | |
|---|---|---|---|
| A priori regions of interest * [F(3,12)=13.67, Wilks’ lambda=0.23, p=0.0004] | |||
| Mesiotemporal cortex | 9.69 (0.95) | 7.60 (0.82) | 21.66 |
| L. lateral orbitofrontal cortex | 5.00 (0.48) | 4.11 (0.77) | 17.85 |
| Subgenual anterior cingulate | 7.00 (0.97) | 5.07 (0.61) | 27.60 |
| Post hoc regions of interest * [F(5,10)= 3.24, Wilks’ lambda=.38, p=0.054] | |||
| Pregenual anterior cingulate | 5.80 (0.68) | 4.44 (0.62) | 23.38 |
| R. lateral orbitofrontal cortex | 5.24 (0.64) | 4.01 (0.94) | 23.41 |
| Postcentral gyrus | 4.06 (0.67) | 3.29 (0.56) | 19.13 |
| Occipital cortex | 2.20 (0.26) | 1.78 (0.32) | 19.04 |
| Raphe nucleus (Presynaptic region) | 4.09 (0.45) | 3.66 (0.62) | 10.58 |
*
Multivariate analysis of variance (MANOVA) test of the main effect of depression on 5HT1A receptor BP.